Longitudinal linked read sequencing reveals ecological and evolutionary responses of a human gut microbiome during antibiotic treatment

We are happy to share our latest collaboration examining the evolutionary dynamics in a single indivudual with high-res longitudinal data generated with long-read sequencing technology. Here, we show that genetic compositons within species can change in response to antibiotic perturbations even when the species relative abundance does not change significantly with time (see figure from the paper below). This indicates that the genetic changes observed within microbiomes play an important role in responding to selective pressures.